| I. Willis Cole ( early African-American newspaper entrepreneur) |
| Rhoda Kavanaugh ( educator and entrepreneur) |
| Katherine Pettit ( educator) |
| John Bate (former slave, and educator) |
| Mary Britton (first female African-American physician) |
| Garrett Morgan (inventor of the gas mask, and stop light) |
| Thomas Hunt Morgan (Nobel Prize winning scientist) |
| Benjamin Spencer (former slave, educator and business owner) |
| Lee Wainscott (inventor of Ale-8 One soda) |
| John Colgan (inventor of the flavored chewing gum) |
| John Fitch (inventor of the steamboat) |
| Jennie Benedict (entrepreneur) |
| Carrie Burnam Taylor (entrepreneur) |
| The Hill Sisters ( wrote the Happy Birthday tune) |
| Laura Clay ( Suffragist) |
| Mary Desha ( co-founded the Daughter of the American Revolution) |
| Abraham Lincoln (president) |
| John Fee ( helped found Berea College) |
| Cassius Clay (politician, abolitionist) |
| Emma Clement (first African-American Mother of the Year) |
| Mary Miller (first female steamboat captain) |
| Alice Dunnigan ( journalist) |
| Whitney Young Jr.(civil rights activists) |
| Mary Breckinridge ( founder of the Frontier Nursing Service) |
| Alice Lloyd (educator) |
| Lucy Harth Smith (educator) |
| Albert Meyzeek (educator) |
| Rosa Phillips Stonestreet (Jefferson County superintendent) |
| Enid Yandell (sculptor) |
| Mary Merritt (nurse) |
| Harriette Arnow (author) |
| Clifford Berryman (cartoonist) |
| Charles Anderson (politician) |
| Robert Penn Warren (author) |
| Alexander Boston (dentist) |
| Bill Monroe (Father of Bluegrass music) |
| Isaac Shelby (first governor) |